ROME 7th International Conference on Genetics, Cellular & Molecular Biology (RGCMB-27)

Call for papers/Topics All Abstracts, Reviews, short articles, Full articles, Posters are welcomed related with any of the following research fields: Foundational & Independent Topics These areas represent the distinct, standalone principles unique to each specific biological level, starting from classical inheritance up to basic cellular mechanics. 1. Genetics (Classical, Transmission, and Population) The study of how traits are passed from generation to generation and how genetic variation behaves in populations. - Mendelian Inheritance: The laws of segregation and independent assortment, monohypbrid and dihybrid crosses, and pedigree analysis. - Non-Mendelian Inheritance: Codominance, incomplete dominance, pleiotropy, epistasis, and sex-linked inheritance. - Gene Mapping and Linkage: Genetic recombination, crossing over, chromosome mapping, and lod scores. - Population Genetics: Allele and genotype frequencies, the Hardy-Weinberg principle, genetic drift, gene flow, and natural selection. - Quantitative Genetics: Continuous variation, polygenic traits, heritability, and phenotypic plasticity. 2. Cellular Biology The study of cell structure, basic physiological processes, and how cells interact with their microenvironment. - Cell Membrane and Transport: Phospholipid bilayer dynamics, active and passive transport, endocytosis, and exocytosis. - Organelle Structure and Function: The roles of the nucleus, mitochondria, ribosomes, endoplasmic reticulum, Golgi apparatus, lysosomes, and peroxisomes. - Cytoskeleton and Motility: Microtubules, microfilaments, intermediate filaments, motor proteins (kinesin, dynein, myosin), and cell movement. - Cell Cycle and Division: Phases of the cell cycle (G1, S, G2, M), the mechanics of mitosis and meiosis, and cell cycle checkpoints. - Cell Death and Senescence: Apoptosis (programmed cell death pathways), necrosis, autophagy, and cellular aging. 3. Molecular Biology (Basic Structural Foundations) The physical chemistry and mechanics of the vital macromolecules that store and process life's information. - Structure of Nucleic Acids: Chemical composition of DNA and RNA, double-helix topology, supercoiling, and chromatin packaging. - DNA Replication: Semi-conservative replication mechanics, replication forks, leading and lagging strand synthesis, and enzymatic machinery (DNA polymerases, helicase, primase, ligase). - DNA Damage and Repair: Mechanisms of mutation (mismatch, deamination, UV damage) and repair pathways (mismatch repair, excision repair, double-strand break repair). - Protein Structure and Biophysics: Primary, secondary, tertiary, and quaternary folding structures, peptide bond chemistry, and molecular chaperones. Interrelated & Integrated Topics These fields represent the massive overlap where genetics, cell biology, and molecular mechanics converge to run the living cell. 1. Molecular Genetics and Gene Expression The molecular execution of genetic instructions, linking DNA code directly to cellular function. - Transcription: RNA polymerase mechanisms, promoter and enhancer recognition, and transcription factors in prokaryotes and eukaryotes. - Post-Transcriptional Processing: Pre-mRNA splicing, alternative splicing (generating protein diversity), 5' capping, and 3' polyadenylation. - Translation (Protein Synthesis): Ribosome assembly, tRNA charging by aminoacyl-tRNA synthetases, translation initiation, elongation, and termination. - Post-Translational Modifications: Protein targeting and localization, phosphorylation, glycosylation, ubiquitination, and proteasomal degradation. 2. Epigenetics and Chromatin Dynamics The interface of cellular environment and molecular structure, controlling how genes are accessed without changing the underlying DNA sequence. - Histone Modification: Acetylation, methylation, and phosphorylation of histone tails, and their effects on euchromatin and heterochromatin states. - DNA Methylation: CpG islands, gene silencing, genomic imprinting, and transgenerational epigenetic inheritance. - Chromatin Remodeling Complexes: ATP-dependent remodeling complexes (e.g., SWI/SNF) that physically slide or eject nucleosomes. - Non-coding RNAs: The regulatory roles of microRNAs (miRNAs), small interfering RNAs (siRNAs), and long non-coding RNAs (lncRNAs) in gene silencing. 3. Cell Signaling, Cancer, and Disease Genetics The study of how cells process molecular information from their surroundings, and what happens when these genetic and cellular pathways break down. - Signal Transduction Pathways: G-protein coupled receptors (GPCRs), receptor tyrosine kinases (RTKs), and intracellular secondary messengers (cAMP, Ca2+). - Oncogenes and Tumor Suppressor Genes: Genetic mutations leading to cancer, focusing on cell cycle regulators like p53, Rb, and Ras. - Immunogenetics: The genetic basis of the immune response, V(D)J recombination, antibody diversity, and major histocompatibility complex (MHC) function. - Medical Genetics: Monogenic vs. polygenic human diseases, gene-environment interactions, and molecular diagnostics. 4. Genomics, Bioinformatics, and Biotechnology The scaled-up, computational, and applied integration of these three fields to manipulate and understand life at a systems level. - Recombinant DNA Technology: Cloning vectors, restriction enzymes, Polymerase Chain Reaction (PCR), and site-directed mutagenesis. - High-Throughput Sequencing and Genomics: Next-Generation Sequencing (NGS), transcriptomics (RNA-Seq), and functional genomics. - Gene Editing and Therapy: CRISPR-Cas9 mechanics, base editing, prime editing, and viral vector delivery systems for gene therapy. - Systems Biology: Computational modeling of metabolic networks, proteomics, interactomics, and synthetic biology.